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Coexistence of catecholamines and serotonin with substance P in cerebrospinal fluid of patients with multiple sclerosis or Parkinson's disease

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In this study, the correlation between noradrenaline, dopamine, serotonin and substance P are studied in the cerebrospinal fluid from healthy subjects and patients with Parkinson's disease or multiple sclerosis. The results obtained showed linear relationships of substance P with the levels of noradrenaline, dopamine and serotonin in healthy subjects and all patient groups. The results can help in the understanding of cotransmission between amines and neuropeptide and the results could be taken into consideration prior to the designing of a therapeutic approach.


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