Cookies Policy
X

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

Corticotropin releasing-factor (CRF) increases extracellular GABA levels in the rat hypothalamus

No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.

Brill’s MyBook program is exclusively available on BrillOnline Books and Journals. Students and scholars affiliated with an institution that has purchased a Brill E-Book on the BrillOnline platform automatically have access to the MyBook option for the title(s) acquired by the Library. Brill MyBook is a print-on-demand paperback copy which is sold at a favorably uniform low price.

Access this article

+ Tax (if applicable)
Add to Favorites
You must be logged in to use this functionality

image of Biogenic Amines

We investigated the effect of the perfusion of corticotropin releasing-factor (CRF) on the extracellular levels of γ-aminobutyric acid (GABA) in the hypothalamic paraventricular nucleus in the rat using a microdialysis technique. Local perfusion of CRF (3 μM, 10 μM and 30 μM) caused significant increases in extracellular GABA levels in a dose dependent manner. Increases in GABA levels in this region caused by CRF were significantly reduced by the presence of [D-Phe12, Nle21,38, α-Me-Leu37]-CRF (12-41) (D-Phe CRF12-41, 1 μM), a CRF receptor antagonist. These findings suggest that CRF activates GABAergic neurons in the rat hypothalamic paraventricular nucleus via CRF receptors, which might be related to regulation of ACTH secretion in the anterior lobe of the pituitary.

10.1163/156939102762853454
/content/journals/10.1163/156939102762853454
dcterms_title,pub_keyword,dcterms_description,pub_author
6
3
Loading
Loading

Full text loading...

/content/journals/10.1163/156939102762853454
Loading

Data & Media loading...

http://brill.metastore.ingenta.com/content/journals/10.1163/156939102762853454
Loading

Article metrics loading...

/content/journals/10.1163/156939102762853454
2002-04-01
2016-12-04

Sign-in

Can't access your account?
  • Tools

  • Add to Favorites
  • Printable version
  • Email this page
  • Subscribe to ToC alert
  • Get permissions
  • Recommend to your library

    You must fill out fields marked with: *

    Librarian details
    Your details
    Why are you recommending this title?
    Select reason:
     
    Biogenic Amines — Recommend this title to your library
  • Export citations
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation