Cookies Policy

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

The effect of melatonin and corticosterone on the phagocytic function of BALB/c mice macrophages

No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.

Brill’s MyBook program is exclusively available on BrillOnline Books and Journals. Students and scholars affiliated with an institution that has purchased a Brill E-Book on the BrillOnline platform automatically have access to the MyBook option for the title(s) acquired by the Library. Brill MyBook is a print-on-demand paperback copy which is sold at a favorably uniform low price.

Access this article

+ Tax (if applicable)
Add to Favorites
You must be logged in to use this functionality

image of Biogenic Amines

The hormones melatonin and corticosterone are able to modulate the immune response, with indications that melatonin may counteract the immunosuppressory action of the glucocorticoids. The aim of the present study is to evaluate the effects of pharmacological concentrations of melatonin and corticosterone, singly and together, on macrophage phagocytosis of antigen particles. To this end we performed an in vitro study using as phagocytes peritoneal macrophages from two groups of BALB/c mice, one in a basal situation and the other subjected to stress by swimming. The concentrations used were ten and one hundred times greater than the previously determined physiological levels. In particular, for incubations with macrophages from the basal group they were 0.9 pg/ml and 9 pg/ml of melatonin, and 2 μg/ml and 20 μg/ml of corticosterone, and for macrophages from the stressed group they were 0.7 pg/ml and 7 pg/ml of melatonin, and 5 μg/ml or 50 μg/ml of corticosterone. The results indicate that the immunomodulatory effect of the two hormones depends on the conditions of the study. Thus, melatonin led to increased phagocytic capacity in macrophages from both the basal and the stressed animals, while corticosterone only had an immunostimulatory effect with macrophages from the unstressed animals. With both hormones acting together, the macrophage phagocytic activity was stimulated at all the concentrations used and independently of whether or not the corresponding animals had been stressed, although the greatest activation was seen in the basal animal phagocytes incubated with the higher corticosterone concentration. In conclusion, while melatonin was definitely immunostimulatory at the concentrations tested, the immunoregulatory properties of corticosterone depended on the situation.


Full text loading...


Data & Media loading...

Article metrics loading...



Can't access your account?
  • Tools

  • Add to Favorites
  • Printable version
  • Email this page
  • Subscribe to ToC alert
  • Get permissions
  • Recommend to your library

    You must fill out fields marked with: *

    Librarian details
    Your details
    Why are you recommending this title?
    Select reason:
    Biogenic Amines — Recommend this title to your library
  • Export citations
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation