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Cobalamin deficiency and its dynamic impact on neurotoxicity and oxidative stress in Parkinson's patients in on-off status on L-dopa treatment

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L-Dopa is considered to be one of the best drug therapies in treating Parkinson's patients with positive outcome in the beginning of its treatment. However, as long period of treatment has shown results with both on and off phenomena and high doses show various side effects. In this study, both On and Off PD patients are investigated to determine the role of biochemical markers such as cobalamin (Vitamin B12) and homocysteine in the cerebrospinal fluid (CSF). These biochemical changes in the CSF could be considered as vital information in designing new drugs in treating these patients for a longer period.


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