Cookies Policy

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

Effect of adrenergic and cholinergic agonists on vasoactive intestinal polypeptide release from pancreatic islets of normal and diabetic rats

No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.

Brill’s MyBook program is exclusively available on BrillOnline Books and Journals. Students and scholars affiliated with an institution that has purchased a Brill E-Book on the BrillOnline platform automatically have access to the MyBook option for the title(s) acquired by the Library. Brill MyBook is a print-on-demand paperback copy which is sold at a favorably uniform low price.

This Article is currently unavailable for purchase.
Add to Favorites
You must be logged in to use this functionality

Background and aims: Vasoactive intestinal polypeptide (VIP) is present in pancreatic islet cells and stimulates insulin and glucagon release from normal and diabetic rats. The aim of this study was to examine the effect of noradrenaline (NA) and acetylcholine (ACh) on VIP release from pancreatic islets of normal and diabetic rats.

Methods: NA- and ACh-induced VIP release from isolated pancreatic tissue fragments was measured using radioimmunoassay technique.

Results: The basal VIP release from the islets of diabetic rats was significantly (p = 0.02) higher compared to normal. NA at and 10-6 M also evoked large and significant (p = 0.04) increases in VIP release from the islets of normal rat. Moreover, NA at 10-8 M, significantly (p < 0.05) stimulated VIP release from the islets of diabetic rats. ACh (10-4 M), induced up to 46.6% increase in VIP secretion from the islet cells of normal (n = 6) rats. However, a more dilute concentration of ACh (10-8 M) was sufficient for the induction of maximal VIP secretion from the isolated islets of diabetic (n = 6) rat. ACh (10-6 M) evoked 32.3% increase in VIP secretion in diabetic rat islets.

Conclusion: NA and ACh stimulated VIP secretion from pancreatic islets of normal rat. NA and ACh can also induce increases in VIP secretion from the islets of diabetic rat. The increase in VIP in the islets of diabetic rats may also play a role in the pathogenesis of diabetic complications.


Full text loading...


Data & Media loading...

Article metrics loading...



Can't access your account?
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation