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Central and peripheral sympathetic controls on catecholamine release in male 2-month-old SHRSP and WKY investigated by means of 6-hydrodydopamine injections

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In order to investigate the role of central and peripheral sympathetic activities in stroke-prone spontaneously hypertensive rats (SHRSP), maximum dose of 6-OHDA was injected into a lateral cerebral ventricle (i.c.v.) or a peritoneal cavity (i.p.), and changes of catecholamine metabolites in the brain, adrenal glands, plasma, and urine were measured and analyzed. 6-OHDA i.c.v. showed no changes in blood pressure, but showed a tendency to lower heart rates, and a significant decrease in NE in the brain and plasma in SHRSP. On the other hand, 6-OHDA i.p. showed a significant decline of blood pressure, an increase in heart rate, and a decrease of Ep in plasma without effects on NE level in SHRSP. These findings indicate that (1) 6-OHDA i.p. treatment destroys the accessory or extra-adrenal glands besides peripheral sympathetic nerves; (2) Ep is released from the extra-secretary organs, and contributes to maintaining the hypertension in SHRSP; (3) 6-OHDA i.c.v. destroys the central sympathetic nerves and inhibits temporally the peripheral sympathetic activity, adrenal glands and the accessory or extra-adrenal glands; and (4) peripheral sympathetic nerve function works to maintain hyper-sympathetic states in SHRSP.

10.1163/1569391041501771
/content/journals/10.1163/1569391041501771
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/content/journals/10.1163/1569391041501771
2004-06-01
2016-12-11

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