Cookies Policy

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

Central and peripheral sympathetic controls on catecholamine release in male 2-month-old SHRSP and WKY investigated by means of 6-hydrodydopamine injections

No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.

Brill’s MyBook program is exclusively available on BrillOnline Books and Journals. Students and scholars affiliated with an institution that has purchased a Brill E-Book on the BrillOnline platform automatically have access to the MyBook option for the title(s) acquired by the Library. Brill MyBook is a print-on-demand paperback copy which is sold at a favorably uniform low price.

This Article is currently unavailable for purchase.
Add to Favorites
You must be logged in to use this functionality

In order to investigate the role of central and peripheral sympathetic activities in stroke-prone spontaneously hypertensive rats (SHRSP), maximum dose of 6-OHDA was injected into a lateral cerebral ventricle (i.c.v.) or a peritoneal cavity (i.p.), and changes of catecholamine metabolites in the brain, adrenal glands, plasma, and urine were measured and analyzed. 6-OHDA i.c.v. showed no changes in blood pressure, but showed a tendency to lower heart rates, and a significant decrease in NE in the brain and plasma in SHRSP. On the other hand, 6-OHDA i.p. showed a significant decline of blood pressure, an increase in heart rate, and a decrease of Ep in plasma without effects on NE level in SHRSP. These findings indicate that (1) 6-OHDA i.p. treatment destroys the accessory or extra-adrenal glands besides peripheral sympathetic nerves; (2) Ep is released from the extra-secretary organs, and contributes to maintaining the hypertension in SHRSP; (3) 6-OHDA i.c.v. destroys the central sympathetic nerves and inhibits temporally the peripheral sympathetic activity, adrenal glands and the accessory or extra-adrenal glands; and (4) peripheral sympathetic nerve function works to maintain hyper-sympathetic states in SHRSP.


Full text loading...


Data & Media loading...

Article metrics loading...



Can't access your account?
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation