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Na+-K+ pump and β-adrenergic responses in smooth muscle

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Changes in Na+-K+ pump activity influence intracellular Na+ and K+ concentrations. Activation of the electrogenic Na+-K+ pump hyperpolarizes plasma membrane and inhibits voltage-dependent Ca2+ current. Na+-K+ pump activity has been shown to be inhibited in the absence of extracellular K+ or by cardiac glycosides. Involvement of Na+-K+ pump in regulation of cellular functions has been identified by inhibition of responses under inhibition of the Na+-K+ pump. In some smooth muscle tissues, responses to β-agonists were inhibited by K+-free medium or ouabain, indicating that responses to β-adrenoceptor agonists are mediated by the Na+-K+ pump. However, in other smooth muscle tissues, responses to β-agonists were not inhibited by Na+-K+ pump inhibition. The Na+-K+ pump plays an important role in the regulation of circulatory function, and the levels of endogenous Na+-K+ pump inhibitors have been shown to be elevated in some types of hypertension. Endogenous Na+-K+ pump inhibitors possibly affect some of β-adrenoceptor-mediated responses. Regulation of Na+-K+ pump may be important in the regulation of smooth muscle activity in normal conditions, as well as under pathophysiological conditions, such as hypertension.


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