Cookies Policy

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

The ferret: a cytotoxic drug-induced emesis model

No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.

Brill’s MyBook program is exclusively available on BrillOnline Books and Journals. Students and scholars affiliated with an institution that has purchased a Brill E-Book on the BrillOnline platform automatically have access to the MyBook option for the title(s) acquired by the Library. Brill MyBook is a print-on-demand paperback copy which is sold at a favorably uniform low price.

Access this article

+ Tax (if applicable)
Add to Favorites
You must be logged in to use this functionality

image of Biogenic Amines

The ferret (Mustela putorius furo), a carnivore weighting 1–1.5 kg, is highly valued as a small animal model for determining the emetic activity of cytotoxic drugs. Because of its sensitivity to emetic stimuli, the ferret is now being used routinely for testing novel cytotoxic drugs and antiemetic agents. In our laboratory, ferrets were evaluated on their behavioral changes, pathological changes and pharmacological responses to cytotoxic drug-induced emesis. Cisplatin-induced emesis in ferrets was inhibited by 5-HT3 receptor antagonists in a dose dependent manner. 5-HT levels in the area postrema and in the ileum were increased by cytotoxic agents. Both abdominal vagotomy and ondansetron, a 5-HT3 receptor antagonist, remarkably inhibited cisplatin-induced emesis and cisplatin-induced increase in 5-HT levels in the area postrema. The cisplatin-induced increase of the ileal 5-HT levels, however, was not inhibited by vagotomy or ondansetron. Furthermore, compared with intraperitoneal administration, oral administration of ondansetron blocked cyclophosphamide-induced emesis more effectively and significantly. These results suggest that cytotoxic drugs induce emesis mainly through actions on the gastrointestinal tract. Cytotoxic drugs may cause 5-HT release from the enterochromaffin (EC) cells of the intestinal mucosa to stimulate 5-HT3 receptors on the afferent vagal fibers. Stimulation from the afferent vagal nerves appear to produce an increase in 5-HT levels in the area postrema. The increased 5-HT levels in the area postrema might trigger the emetic response induced by cytotoxic agents. In this review, we also discuss abdominal afferent vagus nerve activity and 5-HT release from EC cells using data from our laboratory.


Full text loading...


Data & Media loading...

Article metrics loading...



Can't access your account?
  • Tools

  • Add to Favorites
  • Printable version
  • Email this page
  • Subscribe to ToC alert
  • Get permissions
  • Recommend to your library

    You must fill out fields marked with: *

    Librarian details
    Your details
    Why are you recommending this title?
    Select reason:
    Biogenic Amines — Recommend this title to your library
  • Export citations
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation