Cookies Policy
X

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

Effects of serotonin (5-HT) on catecholamine secretion from cultured bovine chromaffin cells

No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.

Brill’s MyBook program is exclusively available on BrillOnline Books and Journals. Students and scholars affiliated with an institution that has purchased a Brill E-Book on the BrillOnline platform automatically have access to the MyBook option for the title(s) acquired by the Library. Brill MyBook is a print-on-demand paperback copy which is sold at a favorably uniform low price.

This Article is currently unavailable for purchase.
Add to Favorites
You must be logged in to use this functionality

Effects of serotonin (5-hydroxytryptamine, 5-HT) on catecholamine (CA) secretion were examined in cultured bovine adrenal chromaffin cells. Although 5-HT itself did not increase CA secretion, 5-HT significantly inhibited acethylcholine-induced CA secretion and 5-HT blocked nicotine-evoked CA release in a dose-dependent manner. Co-incubation with muscarine and 5-HT did not increase CA secretion. At a high dose only, 5-HT inhibited high K+ (56 mM) and veratridine-induced CA release, but 5-HT did not affect secretion induced by Ca2+-ionophore A23187. Furthermore, 5-HT dose-dependently inhibited the nicotine-induced rise of intracellular free Ca2+ ([Ca2+]i), as well as the CA secretion elicited by nicotine. Lineweaver–Burk Plot analysis demonstrated that 5-HT non-competitively inhibited nicotine-induced CA release. These findings suggest that 5-HT inhibits nicotine-induced CA secretion and increases intracellular free Ca2+ in adrenal chromaffin cells by non-competitive inhibition of nicotinic acetylcholine-receptor.

10.1163/1569391041501889
/content/journals/10.1163/1569391041501889
dcterms_title,pub_keyword,dcterms_description,pub_author
10
5
Loading
Loading

Full text loading...

/content/journals/10.1163/1569391041501889
Loading

Data & Media loading...

http://brill.metastore.ingenta.com/content/journals/10.1163/1569391041501889
Loading

Article metrics loading...

/content/journals/10.1163/1569391041501889
2017-10-20

Sign-in

Can't access your account?
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation