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Effects of serotonin (5-HT) on catecholamine secretion from cultured bovine chromaffin cells

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Effects of serotonin (5-hydroxytryptamine, 5-HT) on catecholamine (CA) secretion were examined in cultured bovine adrenal chromaffin cells. Although 5-HT itself did not increase CA secretion, 5-HT significantly inhibited acethylcholine-induced CA secretion and 5-HT blocked nicotine-evoked CA release in a dose-dependent manner. Co-incubation with muscarine and 5-HT did not increase CA secretion. At a high dose only, 5-HT inhibited high K+ (56 mM) and veratridine-induced CA release, but 5-HT did not affect secretion induced by Ca2+-ionophore A23187. Furthermore, 5-HT dose-dependently inhibited the nicotine-induced rise of intracellular free Ca2+ ([Ca2+]i), as well as the CA secretion elicited by nicotine. Lineweaver–Burk Plot analysis demonstrated that 5-HT non-competitively inhibited nicotine-induced CA release. These findings suggest that 5-HT inhibits nicotine-induced CA secretion and increases intracellular free Ca2+ in adrenal chromaffin cells by non-competitive inhibition of nicotinic acetylcholine-receptor.


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