Cookies Policy

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

An α2-adrenoceptor inhibits noradrenaline (NA) release in the locus coeruleus (LC) of the rat brain assessed by in vivo microdialysis

No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.

Brill’s MyBook program is exclusively available on BrillOnline Books and Journals. Students and scholars affiliated with an institution that has purchased a Brill E-Book on the BrillOnline platform automatically have access to the MyBook option for the title(s) acquired by the Library. Brill MyBook is a print-on-demand paperback copy which is sold at a favorably uniform low price.

Access this article

+ Tax (if applicable)
Add to Favorites
You must be logged in to use this functionality

image of Biogenic Amines

The regulation of α2-adrenoceptors on somatodendritic noradrenaline (NA) release from the locus coeruleus (LC) of conscious and freely moving rats was studied by using in vivo microdialysis. The concentration of NA in the dialysate (20 min/sample) from LC was measured by HPLC combined with electrochemical detection. The extracellular NA levels were completely abolished by tetrodotoxin (TTX, 1 μM for 120 min) perfused locally to LC via the dialysis membrane. The perfusion of clonidine (100μM for 60 min), an α2-adrenoceptor agonist, in LC resulted in significant decreases in the extracellular NA levels in LC, whereas significant increase in NA levels was brought when yohimbine (100 μM for 60 min), an alpha;2-adrenoceptor antagonist, was perfused to the nucleus. These results suggest that NA present in the extracellular space is released in LC and this release receives inhibitory regulation via α2-adrenoceptor located on somatodendrites in LC.


Full text loading...


Data & Media loading...

Article metrics loading...



Can't access your account?
  • Tools

  • Add to Favorites
  • Printable version
  • Email this page
  • Subscribe to ToC alert
  • Get permissions
  • Recommend to your library

    You must fill out fields marked with: *

    Librarian details
    Your details
    Why are you recommending this title?
    Select reason:
    Biogenic Amines — Recommend this title to your library
  • Export citations
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation