Cookies Policy

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

Association of human renin gene haplotype with essential hypertension in an isolated population

No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.

Brill’s MyBook program is exclusively available on BrillOnline Books and Journals. Students and scholars affiliated with an institution that has purchased a Brill E-Book on the BrillOnline platform automatically have access to the MyBook option for the title(s) acquired by the Library. Brill MyBook is a print-on-demand paperback copy which is sold at a favorably uniform low price.

Access this article

+ Tax (if applicable)
Add to Favorites
You must be logged in to use this functionality

image of Biogenic Amines

Among the many candidates that could be implicated in underlying an individual's genetic susceptibility to human essential hypertension (EHT), the renin gene (REN) is particularly appealing because of its central role in the renin-angiotensin-aldosterone system and of its demonstrated functional role in hypertensive animal models.

We had previously shown that two dimorphic sites of the human REN gene (BglI in intron 1 and MboI in intron 9) were individually associated with hypertension in two independent populations.

We used here a retrospective, case-control design to investigate the haplotype distributions of alleles combining BglI and MboI sites in two groups of subjects (144 hypertensives and 96 normotensives) from the United Arab Emirates (UAE), a genetically homogeneous ethnic population with no history of smoking or alcohol consumption. There was a marked difference in the distribution of haplotypes among normotensive vs. hypertensive subjects (χ2 = 29.87, 3 df, p=10−6). The odds ratio of the association of [BglI(+)-MboI(+)] haplotypes with increased risk for hypertension was 4.43 (95% CI: 2.41–8.19, Yates-corrected p = 3 × 10−7).

Genetic variations of the REN (or of a nearby) gene that may be in linkage disequilibrium with REN [BglI(+)-MboI(+)] alleles could play a role in contributing to increased individual's genetic susceptibility to EHT among UAE nationals studied here.


Full text loading...


Data & Media loading...

Article metrics loading...



Can't access your account?
  • Tools

  • Add to Favorites
  • Printable version
  • Email this page
  • Subscribe to ToC alert
  • Get permissions
  • Recommend to your library

    You must fill out fields marked with: *

    Librarian details
    Your details
    Why are you recommending this title?
    Select reason:
    Biogenic Amines — Recommend this title to your library
  • Export citations
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation