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Effect of Moringa oleifera root extract on penicillin-induced epileptic rats

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Effect of chronic treatment of aqueous extract root extract of Moringa oleifera (350 mg/kg) on penicillin-induced convulsion and the changes of EEG pattern and brain serotonin (5-HT), dopamine (DA) and norepinephrine (NE) level were studied in Holtzman strain adult albino rats of both sexes. The results revealed that pretreatment with Moringa oleifera (MO) inhibited penicillin-induced seizure and decreased the number and duration of spike wave discharges. Moringa oleifera significantly increased the NE level in cerebral cortex (CC) and midbrain (MB) and decreased that in the cerebellum (CB). Similarly, dopamine level significantly increased in MB and CB and decreased in CC and caudate nucleus (CN) and 5-HT level significantly increased in all four brain regions.

Thus Moringa oleifera suppresses penicillin-induced epileptic seizure by changing the electrical activity and by altering the 5-HT, norepinephrine and dopamine balance.


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