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The role of iron, copper and zinc and their effects in on/off Parkinson's patients on L-dopa therapy

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We have quantified levels of iron, copper and zinc in cerebrospinal fluid (CSF) and serum by atomic absorption spectrophotometer in 36 patients with Parkinson's disease (PD), all on L-dopa therapy. Out of these 36, 17 showed On or positive response to L-dopa whereas 19 patients showed On and Off response. These data were compared with 21 healthy controls. The results showed that serum levels of iron, copper as well zinc remained unchanged whereas in CSF, a significant decrease in zinc was found in both On and On/Off PD patients, indicating the deficiency of zinc which continues in the detoriating clinical condition of Off patients. The level of copper remained unchanged in both On and On/Off PD patients. Iron increases in CSF of both patients, which is clear evidence of a relationship between increased iron level in brain that could be corrolated with decrease in dopamine levels and oxidative stress in PD Patients.


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