Cookies Policy
X

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

The role of iron, copper and zinc and their effects in on/off Parkinson's patients on L-dopa therapy

No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.

Brill’s MyBook program is exclusively available on BrillOnline Books and Journals. Students and scholars affiliated with an institution that has purchased a Brill E-Book on the BrillOnline platform automatically have access to the MyBook option for the title(s) acquired by the Library. Brill MyBook is a print-on-demand paperback copy which is sold at a favorably uniform low price.

Access this article

+ Tax (if applicable)
Add to Favorites
You must be logged in to use this functionality

image of Biogenic Amines

We have quantified levels of iron, copper and zinc in cerebrospinal fluid (CSF) and serum by atomic absorption spectrophotometer in 36 patients with Parkinson's disease (PD), all on L-dopa therapy. Out of these 36, 17 showed On or positive response to L-dopa whereas 19 patients showed On and Off response. These data were compared with 21 healthy controls. The results showed that serum levels of iron, copper as well zinc remained unchanged whereas in CSF, a significant decrease in zinc was found in both On and On/Off PD patients, indicating the deficiency of zinc which continues in the detoriating clinical condition of Off patients. The level of copper remained unchanged in both On and On/Off PD patients. Iron increases in CSF of both patients, which is clear evidence of a relationship between increased iron level in brain that could be corrolated with decrease in dopamine levels and oxidative stress in PD Patients.

10.1163/156939105774647321
/content/journals/10.1163/156939105774647321
dcterms_title,pub_keyword,dcterms_description,pub_author
6
3
Loading
Loading

Full text loading...

/content/journals/10.1163/156939105774647321
Loading

Data & Media loading...

http://brill.metastore.ingenta.com/content/journals/10.1163/156939105774647321
Loading

Article metrics loading...

/content/journals/10.1163/156939105774647321
2005-12-01
2016-12-07

Sign-in

Can't access your account?
  • Tools

  • Add to Favorites
  • Printable version
  • Email this page
  • Subscribe to ToC alert
  • Get permissions
  • Recommend to your library

    You must fill out fields marked with: *

    Librarian details
    Your details
    Why are you recommending this title?
    Select reason:
     
    Biogenic Amines — Recommend this title to your library
  • Export citations
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation