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Immunization efficacy of ozone-exposed cercariae against subsequent Schistosoma mansoni challenge infection

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CD1 mice were immunized subcutaneously with 20 ozone-exposed (70μg/ml, 1 minute exposure) Schistosoma mansoni cercariae weekly/three weeks. The efficacy of immunization was assessed 10 weeks post challenge infection by the determination of the worm burden, ova count, oogram, granuloma diameter, IgG reactions against soluble egg antigen (SEA) and tegument structural changes of recovered worms that are immunized. A reduced worm length and a reduction in worm burden were observed in the immunized group as compared to the infected not immunized group. Moreover, no ova were found in liver and intestine from the immunized mice as compared with infected control mice. Also, immunization with ozonated cercariae showed a decrement in the mean relative weight of liver and spleen. Total leukocyte count was increased in the immunized animal as compared to the infected control. The level of total IgG antibody against SEA decreased in immunized mice as compared with the infected control mice. Scanning electron microscope (SEM) images of worms recovered 10 weeks post challenge from the immunized group revealed extensive tegumental destruction. This study underlines the significant role of ozone attenuated cercariae vaccine against S. mansoni infection, which generated specific immunity with a significant level of protection.

Affiliations: 1: Department of Zoology, Faculty of Science, Menoufia University, Shebin El-Kom, Menoufia, Egypt;, Email:


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