Cookies Policy
X
Cookie Policy

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

Changes in the hepatic and renal structure and function after a growth promoter boldenone injection in rabbits

MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.

Buy this article

Price:
$30.00+ Tax (if applicable)
Add to Favorites

image of Animal Biology
For more content, see Archives Néerlandaises de Zoologie (Vol 1-17) and Netherlands Journal of Zoology (Vol 18-52).

Boldenone is an androgenic steroid that improves the growth and food conversion in food producing animals. In most countries worldwide, this anabolic steroid is forbidden for meat production. Recently, it is used by bodybuilders in both off-season and pre-contest, where it is well known for increasing vascularity while preparing for a bodybuilding contest. Therefore, our study was designed to investigate the possible effect of using growth promoter boldenone undecylenate on the rabbit liver and kidney structure and functions. Thirty-two adult New Zealand rabbits were divided into four groups. Control group includes animals that injected intramuscularly with olive oil and dissected after 3 weeks. Three experimental groups include animals that receive one, two and three intramuscular injections of 5 mg/kg body weight boldenone, respectively and dissected after 3, 6 and 9 weeks respectively, where the interval of each dose of boldenone was three weeks. Intramuscular injection of rabbits with boldenone increased the serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), urea and creatinine compared with the control group. We also found significant increases in the total protein, total lipid, nitric oxide (NO), superoxide dismutase activity (SOD), glutathione (GSH) and malondialdehyde (MDA) in liver and kidney tissues compared with the control group. Intramuscular injection of rabbits with boldenone exhibited mild to severe histopathological lesions in liver tissue as hepatocellular vacuolation in the centrilobular region and sinusoids and in the kidney, the renal glomerulei had completely lost their typical shape with the appearance of some vacuoles of different shapes and sizes with markedly congested sinusoidal and dilated blood vessels. These findings suggest that misuse of growth promoter boldenone undecylenate may contribute to continuous damage of the hepatic and renal function and structure that may lead to a progressive hepatic and renal diseases, so people should be careful if they want to use such steroids to enhance their strength and endurance.

Affiliations: 1: 1Animal Production Department, Faculty of Agriculture, Minoufiya University, Egypt; 2: 2Department of Zoology, Faculty of Science, Tanta University, Egypt; 3: 3Biochemistry Section, Department of Chemistry, Faculty of Science, Tanta University, Egypt

Sign-in

Can't access your account?
  • Tools

  • Add to Favorites
  • Printable version
  • Email this page
  • Create email alert
  • Get permissions
  • Recommend to your library

    You must fill out fields marked with: *

    Librarian details
    Name:*
    Email:*
    Your details
    Name:*
    Email:*
    Department:*
    Why are you recommending this title?
    Select reason:
     
     
     
     
    Other:
     
    Animal Biology — Recommend this title to your library

    Thank you

    Your recommendation has been sent to your librarian.

  • Export citations
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation