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Some Effects of Piperazine and Methyridine On the Free-Living Nematode Caenorhabditis Briggsae (Rhabditidae)

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Some biological effects of methyridine and piperazine on Caenorhabditis briggsae have been investigated using in vitro techniques on intact worms. It has been found that methyridine produces a contracted paralysis which is not reversed in drug-free medium and piperazine produces a flaccid paralysis reversible in drug-free medium. Methyridine and piperazine negate the action of each other competitively. Different types of evidence have been presented and discussed to show that drugs affect the neuromuscular system of C. briggsae, methyridine being a depolarizing agent and piperazine a neuro-muscular junction blocking agent.

Affiliations: 1: Department of Zoology, University of Illinois, Urbana, Illinois, U.S.A


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