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Effects of Dna Synthesis Inhibitors On Caenorhabditis Briggsae and Turbatrix Aceti

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image of Nematologica
For more content, see Nematology.

The effects of three DNA synthesis inhibitors on axenically grown Caenorhabditis briggsae and Turbatrix aceti were evaluated. Lower dosages of aminopterin sometimes prevented vagina formation and the eggs hatched within the oviduct. Concentrations of aminopterin, 5-fluorodeoxyuridine and hydroxyurea which prevented reproduction, caused significant growth inhibition, prevented maturation past the third larval stage, and reduced longevity. A difference in physiologic state was indicated by the inability of aminopterin treated Caenorhabditis briggsae to adjust to osmotic pressures tolerated by untreated nematodes. These studies indicate the difficulties inherent in utilizing age-synchronous nematode cultures produced by the application of DNA synthesis inhibitors.

Affiliations: 1: Laboratory of Experimental Biology, University of Massachusetts, East Wareham, Massachusetts, U.S.A.


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