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Effects of Procaine On the Development, Longevity and Fecundity of Caenorhabditis Elegans

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image of Nematologica
For more content, see Nematology.

In medium containing 20 mg/ml of procaine-HCl, juvenile development of Caenorhabditis elegans almost ceased, and juveniles entered a dauer-like state. After transfer to procaine-free medium, the nematodes resumed growth and matured in about 4 days. After transfer to drug-free medium the fecundity of the treated nematodes was markedly reduced even by a one-day exposure to the drug, and unlike longevity the decline proceeded stepwise. Procaine-treated nematodes resisted desiccation less but resisted freezing as did juveniles in the dauer state from monoxenic cultures. Under the electron microscope procaine-treated juveniles had empty intestinal lumens but unlike dauer juveniles the morphology of this region had a thin cuticle and no lateral alae.

Affiliations: 1: Aburahi Laboratories, Shionogi Research Laboratories, Shionogi & Co., Ltd., Koka-cho, Shiga 520-34 Japan; 2: Laboratory of Nematology and Entomology, Faculty of Agriculture, Saga University, Saga 840 Japan


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