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New Findings on the Sensitivity of Free-Operant Timing Behaviour to 5-Hydroxytryptamine Receptor Stimulation

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Timing performance maintained under the free-operant psychophysical procedure (FOPP) is sensitive to 5-hydroxytryptamine (5-HT)1A and 5-HT2A receptor stimulation. Agonists of these receptors displace the psychometric function towards shorter durations, reducing T50, the index of central tendency of timing. Here we report the effects of Ro-600175, a selective 5-HT2C receptor agonist, and mCPP, a 5-HT receptor agonist with high affinity for 5-HT2C receptors and lower affinity for 5-HT1A, 5-HT1B and 5-HT2A receptors, on timing behaviour. Rats were trained under the FOPP to press two levers (A and B) in 50-s trials in which reinforcers were provided intermittently for responding on A in the first half, and B in the second half of the trial. Percent responding on B (%B) was recorded in successive 5-s epochs of the trials; logistic psychometric curves were fitted to the data from each rat under each treatment condition for derivation of timing indices [T50 (time corresponding to %B = 50%), Weber fraction]. The rats received systemic treatment with Ro-600175, mCPP, and mCPP in combination with antagonists of 5-HT1A (WAY-100635), 5-HT1B (isamoltane), 5-HT2A (MDL-100907) or 5-HT2C (SB-242084) receptors. mCPP (2.5 mg kg−1 i.p.), but not Ro-600175 (1, 2, 4 mg kg−1 i.p.), reduced T50. SB-242084 (0.6 mg kg−1 i.p.) potentiated mCPP’s effect on T50. mCPP’s effect on T50 was not altered by isamoltane (8.0 mg kg−1 i.p.), but was attenuated by MDL-100907 (1.0 mg kg−1 i.p.) and WAY-100635 (0.1 mg kg−1 s.c.). The results suggest that mCPP’s effect on timing is mediated by an agonistic action at 5-HT1A and 5-HT2A, but not 5-HT1B, receptors. The role of 5-HT2C receptors is unclear, in view of SB-242084’s ability to potentiate the effect of mCPP, while Ro-600175 had no effect on T50. The possibility is considered that 5-HT2C receptors may counteract 5-HT1A and/or 5-HT2A receptor-mediated effects on timing performance.

Affiliations: 1: 1Psychopharmacology Section, Division of Psychiatry, University of Nottingham, Medical School, Queen’s Medical Centre, Nottingham, NG7 2UH, U.K.; 2: 2School of Biomedical Sciences, University of Nottingham, U.K.; 3: 3Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, The Netherlands


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1. Ahlenius S. , Larsson K. ( 2000). "Stimulation of ejaculatory behaviour by the 5-HT 1Breceptor antagonist isamoltane in citalopram-pretreated male rats". Pharm. Pharmacol. Comm., Vol 6, 317320.
2. Alex K. D. , Pehek E. A. ( 2007). "Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission". Pharmacol. Ther., Vol 113, 296320.
3. Balci F. , Papachristos E. B. , Gallistel C. R. , Brunner D. , Gibson J. , Shumyatsky G. P. ( 2008). "Interval timing in genetically modified mice: A simple paradigm". Genes Brain Behav., Vol 7, 373384.
4. Bizo L. A. , White K. G. ( 1994a). "The behavioral theory of timing: Reinforcer rate determines pacemaker rate". J. Exp. Anal. Behav., Vol 61, 1933.
5. Bizo L. A. , White K. G. ( 1994b). "Pacemaker rate and the behavioral theory of timing". J. Exp. Psych. Anim. Behav. Proc., Vol 20, 308321.
6. Body S. , Asgari K. , Cheung T. H. C. , Bezzina G. , Glennon J. C. , Bradshaw C. M. , Szabadi E. ( 2006a). "Evidence that the effect of 5-HT 2receptor stimulation on temporal differentiation is not mediated by receptors in the dorsal striatum". Behav. Proc., Vol 71, 258267.
7. Body S. , Asgari K. , Rickard J. F. , Zhang Z. , Fone K. C. F. , Bradshaw C. M. , Szabadi E. ( 2005). "Effects of quipazine and m-chlorophenylbiguanide ( m-CPBG) on temporal differentiation: Evidence for the involvement of 5-HT 2Abut not 5-HT 3receptors in interval timing behaviour". Psychopharmacology, Vol 181, 289298.
8. Body S. , Cheung T. H. C. , Bezzina G. , Asgari K. , Fone K. C. F. , Glennon J. C. , Bradshaw C. M. , Szabadi E. ( 2006b). "Effects of d-amphetamine and DOI (2,5-dimethoxy-4-iodoamphetamine) on timing behaviour: Interaction between D 1receptors and 5-HT 2Areceptors". Psychopharmacology, Vol 189, 331343.
9. Body S. , Cheung T. H. C. , Hampson C. L. , den Boon F. S. , Bezzina G. , Fone K. C. F. , Bradshaw C. M. , Szabadi E. ( 2009). "Attenuation of the effects of d-amphetamine on interval timing behaviour by central 5-hydroxytryptamine depletion". Psychopharmacology, Vol 203, 547559.
10. Body S. , Chiang T.-J. , Mobini S. , Ho M.-Y. , Bradshaw C. M. , Szabadi E. ( 2001). "Failure of central 5-hydroxytryptamine depletion to alter the effect of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on timing performance on the free-operant psychophysical procedure". Psychopharmacology, Vol 158, 305313.
11. Body S. , Cheung T. H. C. , Valencia-Torres L. , Olarte-Sanchez C. M. , Fone K. C. F. , Bradshaw C. M. , Szabadi E. ( 2013). "Pharmacological studies of performance on the free-operant psychophysical procedure". Behav. Proc., Vol 95, 7189.
12. Body S. , Kheramin S. , Ho M.-Y. , Miranda Herrera F. , Bradshaw C. M. , Szabadi E. ( 2003). "Effects of a 5-HT 2receptor agonist, DOI (2,5-dimethoxy-4-iodoamphetamine), and antagonist, ketanserin, on the performance on a free-operant timing schedule". Behav. Pharmacol., Vol 14, 599607.
13. Body S. , Kheramin S. , Ho M.-Y. , Miranda Herrera F. , Bradshaw C. M. , Szabadi E. ( 2004). "Effects of fenfluramine on free-operant timing behaviour: Evidence for involvement of 5-HT 2Areceptors". Psychopharmacology, Vol 176, 154165.
14. Body S. , Kheramin S. , Mobini S. , Ho M.-Y. , Velazquez-Martinez D. N. , Bradshaw C. M. , Szabadi E. ( 2002). "Antagonism by WAY-100635 of the effects of 8-OH-DPAT on performance on a free-operant timing schedule in intact and 5-HT-depleted rats". Behav. Pharmacol., Vol 13, 603614.
15. Bubar M. J. , Stutz S. J. , Cunningham K. A. ( 2011). "5-HT 2Creceptors localize to dopamine and GABA neurons in the rat mesoaccumbens pathway". PloS ONE, Vol 6( 6), e20508.
16. Buhusi C. V. ( 2003). "Dopaminergic mechanisms of interval timing and attention". In Meck W. H. (Ed.), Functional and Neural Mechanisms of Interval Timing(pp.  317338). Boca Raton, FL, USA: CRC Press.
17. Buhusi C. V. , Meck W. H. ( 2005). "What makes us tick? Functional and neural mechanisms of interval timing". Nat. Rev. Neurosci., Vol 6, 755765.
18. Cheung T. H. C. , Bezzina G. , Asgari K. , Body S. , Fone K. C. F. , Bradshaw C. M. , Szabadi E. ( 2006). "Evidence for a role of D 1dopamine receptors in d-amphetamine’s effect on timing behaviour in the free-operant psychophysical procedure". Psychopharmacology, Vol 185, 378388.
19. Cheung T. H. C. , Bezzina G. , Body S. , Fone K. C. F. , Bradshaw C. M. , Szabadi E. ( 2007a). "Tolerance to the effect of 2,5-dimethoxy-4-iodoamphetamine (DOI) on free-operant timing behaviour: Interaction between behavioural and pharmacological mechanisms". Psychopharmacology, Vol 192, 521535.
20. Cheung T. H. C. , Bezzina G. , Hampson C. L. , Body S. , Fone K. C. F. , Bradshaw C. M. , Szabadi E. ( 2007b). "Effect of quinpirole on timing behaviour in the free-operant psychophysical procedure: Evidence for the involvement of D 2dopamine receptors". Psychopharmacology, Vol 193, 423436.
21. Cheung T. H. C. , Bezzina G. , Hampson C. L. , Body S. , Fone K. C. F. , Bradshaw C. M. , Szabadi E. ( 2007c). "Evidence for the sensitivity of operant timing behaviour to stimulation of D 1dopamine receptors". Psychopharmacology, Vol 195, 213222.
22. Chiang T.-J. , Al-Ruwaitea A. S. A. , Ho M.-Y. , Bradshaw C. M. , Szabadi E. ( 1998). "The influence of ‘switching’ on the psychometric function in the free-operant psychophysical procedure". Behav. Proc., Vol 44, 197209.
23. Chiang T.-J. , Al-Ruwaitea A. S. A. , Ho M.-Y. , Bradshaw C. M. , Szabadi E. ( 1999). "Effect of central 5-hydroxytryptamine depletion on performance on the free-operant psychophysical procedure: Facilitation of switching, but no effect on temporal differentiation of responding". Psychopharmacology, Vol 143, 166173.
24. Chiang T.-J. , Al-Ruwaitea A. S. A. , Mobini S. , Ho M.-Y. , Bradshaw C. M. , Szabadi E. ( 2000a). "The effect of d-amphetamine on performance on two operant timing schedules". Psychopharmacology, Vol 150, 170184.
25. Chiang T.-J. , Al-Ruwaitea A. S. A. , Mobini S. , Ho M.-Y. , Bradshaw C. M. , Szabadi E. ( 2000b). "Effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on performance on two operant timing schedules". Psychopharmacology, Vol 151, 370391.
26. Coull J. T. , Cheng R. K. , Meck W. H. ( 2011). "Neuroanatomical and neurochemical substrates of timing". Neuropsychopharmacology, Vol 36, 325.
27. Curzon G. , Kennett G. A. ( 1990). "m-CPP: A tool for studying behavioural responses associated with 5-HT 1Creceptors". Trends Pharmacol. Sci., Vol 11, 181182.
28. da Rosa D. D. , Valvassori S. S. , Steckert A. V. , Arent C. O. , Ferreira C. L. , Lopes-Borges J. , Varela R. B. , Mariot E. , Dal-Pizzol F. , Andersen M. L. , Quevedo J. ( 2012). "Differences between dextroamphetamine and methamphetamine: Behavioral changes and oxidative damage in brain of Wistar rats". J. Neural Transm., Vol 119, 3138.
29. Dalton G. L. , Lee M. D. , Kennett G. A. , Dourish C. T. , Clifton P. T. ( 2004). "mCPP-induced hyperactivity in 5-HT2C receptor mutant mice is mediated by activation of multiple 5-HT receptor subtypes". Neuropharmacology, Vol 46, 663671.
30. Damjanoska K. J. , Muma N. A. , Zhang Y. , D’Souza D. N. , Garcia F. , Carrasco G. A. , Kindel G. H. , Haskins K. A. , Shankaran M. , Petersen B. R. , Van De Kar L. D. ( 2003). "Neuroendocrine evidence that (S)-2-(chloro-5-fluoro-indol-l-yl)-1-methylethylamine fumarate (Ro 60-0175) is not a selective 5-hydroxytryptamine 2Creceptor agonist". J. Pharmacol. Exp. Ther., Vol 304, 12091216.
31. Di Matteo V. , Di Giovanni G. , Pierucci M. , Esposito E. ( 2008). "Serotonin control of central dopaminergic function: Focus on in vivo microdialysis studies". Prog. Brain Res., Vol 172, 744.
32. Eshleman A. J. , Henningsen R. A. , Neve K. A. , Janowsky A. ( 1994). "Release of dopamine via the human transporter". Mol. Pharmacol., Vol 45, 312316.
33. Feier G. , Valvassori S. S. , Lopes-Borges J. , Varela R. B. , Bavaresco D. V. , Scaini G. , Morais M. O. , Andersen M. L. , Streck E. L. , Quevedo J. ( 2012). "Behavioral changes and brain energy metabolism dysfunction in rats treated with methamphetamine or dextroamphetamine". Neurosci. Lett., Vol 530, 7579.
34. Fletcher P. J. , Le A. D. , Higgins G. A. ( 2008). "Serotonin receptors as potential targets for modulation of nicotine use and dependence". Prog. Brain Res., Vol 172, 361383.
35. Fletcher P. J. , Rizos Z. , Noble K. , Soko A. D. , Silenieks L. B. , Dzung Lê A. , Higgins G. A. ( 2012). "Effects of the 5-HT 2Creceptor agonist Ro60-0175 and the 5-HT 2Areceptor antagonist M100907 on nicotine self-administration and reinstatement". Neuropharmacology, Vol 62, 22882298.
36. Fletcher P. J. , Sinyard J. , Higgins G. A. ( 2006). "The effects of the 5-HT2C receptor antagonist SB242084 on locomotor activity induced by selective, or mixed, indirect serotonergic and dopaminergic agonists". Psychopharmacology, Vol 187, 515525.
37. Fletcher P. J. , Tampakeras M. , Sinyard J. , Higgins G. A. ( 2007). "Opposing effects of 5-HT 2Aand 5-HT 2Creceptor antagonists in the rat and mouse on premature responding in the five-choice serial reaction time test". Psychopharmacology, Vol 195, 223234.
38. Freestone D. M. , Church R. M. ( 2010). "The importance of the reinforcer as a time marker". Behav. Proc., Vol 84, 500505.
39. Gibbon J. ( 1977). "Scalar expectancy theory and Weber’s law in animal timing". Psychol. Rev., Vol 84, 279325.
40. Gibbon J. ( 1991). "Origins of scalar timing". Learn. Motiv., Vol 22, 338.
41. Goodwin J. S. , Larson G. A. , Swant J. , Sen N. , Javitch J. A. , Zahniser N. R. , De Felice L. J. , Khoshbouei H. ( 2009). "Amphetamine and methamphetamine differentially affect dopamine transporters in vitroand in vivo ". J. Biol. Chem., Vol 284, 29782989.
42. Grottick A. J. , Corrigall W. A. , Higgins G. A. ( 2001). "Activation of 5-HT 2Creceptors reduces the locomotor and rewarding effects of nicotine". Psychopharmacology, Vol 157, 292298.
43. Grottick A. J. , Fletcher P. J. , Higgins G. A. ( 2000). "Studies to investigate the role of 5-HT 2Creceptors on cocaine- and food-maintained behaviour". J. Pharmacol. Exp. Ther., Vol 295, 11831191.
44. Hamik A. , Peroutka S. J. ( 1989). "1-(m-Chlorophenyl)piperazine (mCPP) interactions with neurotransmitter receptors in the human brain". Biol. Psychiat., Vol 25, 569575.
45. Hemrick-Luecke S. K. , Evans D. C. ( 2002). "Comparison of the potency of MDL 100,907 and SB 242084 in blocking the serotonin (5-HT) 2receptor agonist-induced increases in rat serum corticosterone concentrations: Evidence for 5-HT 2Areceptor mediation of the HPA axis". Neuropharmacology, Vol 42, 162169.
46. Higgins G. A. , Ouagazzal A. M. , Grottick A. J. ( 2001). "Influence of the 5-HT 2Creceptor antagonist SB242,084 on behaviour produced by the 5-HT 2agonist Ro60-0175 and the indirect 5-HT agonist dexfenfluramine". Br. J. Pharmacol., Vol 133, 459466.
47. Ho M.-Y. , Body S. , Kheramin S. , Bradshaw C. M. , Szabadi E. ( 2003). "Effects of 8-OH-DPAT and WAY-100635 on performance on a time-constrained progressive-ratio schedule". Psychopharmacology, Vol 167, 137144.
48. Ho M.-Y. , Velazquez-Martinez D. N. , Bradshaw C. M. , Szabadi E. ( 2002). "5-Hydroxytryptamine and interval timing behaviour". Pharmacol. Biochem. Behav., Vol 71, 773785.
49. Hoyer D. ( 1988). "Functional correlates of serotonin 5-HT 1recognition sites". J. Recept. Res., Vol 8, 5981.
50. Hoyer D. , Hannon J. P. , Martin G. R. ( 2002). "Molecular, pharmacological and functional diversity of 5-HT receptors". Pharmacol. Biochem. Behav., Vol 71, 533554.
51. Huang M. , Dai J. , Meltzer H. Y. ( 2011). "5-HT(2A) and 5-HT(2C) receptor stimulation are differentially involved in the cortical dopamine efflux — studied in 5-HT(2A) and 5-HT(2C) genetic mutant mice". Eur. J. Pharmacol., Vol 652, 4045.
52. Kawakami Y. , Kitamura Y. , Araki H. , Kitagawa K. , Suemaru K. , Shibata K. , Gomita Y. ( 2005). "Effects of monoamine reuptake inhibitors on wet-dog shakes mediated by 5-HT 2Areceptors in ACTH-treated rats". Pharmacol. Biochem. Behav., Vol 81, 6570.
53. Kehne J. H. , Baron B. M. , Carr A. A. , Chaney S. F. , Elands J. , Feldman D. J. , Frank R. A. , Van Giersbergen P. L. M. , McCloskey T. C. , Johnson M. P. , McCarty D. R. , Poirot M. , Senyah Y. , Siegel B. W. , Widmaier C. ( 1996). "Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT 2Aantagonist with a favorable CNS safety profile". J. Pharmacol. Exp. Ther., Vol 277, 968981.
54. Kennett G. A. , Wood M. D. , Bright F. , Trail B. , Riley G. , Holland V. , Avenell K. Y. , Stean T. , et al , ( 1997). "SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist". Neuropharmacology, Vol 36, 609620.
55. Khaliq S. , Irfan B. , Haider S. , Halleem D. J. ( 2008). "m-CPP induced hypolomotion does not interfere in the assessment of memory functions in rats". Pak. J. Pharm. Sci., Vol 21, 139143.
56. Killeen P. R. , Fetterman J. G. ( 1988). "A behavioural theory of timing". Psychol. Rev., Vol 95, 274295.
57. Killeen P. R. , Fetterman J. G. , Bizo L. A. ( 1997). "Time’s causes". In Bradshaw C. M. , Szabadi E. (Eds.), Time and Behaviour: Psychological and Neurobehavioural Analyses(pp.  79131). Elsevier, Amsterdam, Netherlands.
58. Kitamura Y. , Araki H. , Suemaru K. , Gomita Y. ( 2002). "Effects of imipramine and lithium on wet-dog shakes mediated by the 5-HT 2Areceptor in ACTH-treated rats". Pharmacol. Biochem. Behav., Vol 72, 397402.
59. López-Giménez J. F. , Vilaró M. T. , Palacios J. M. , Mengod G. ( 1998). "[ 3H]MDL 100,907 labels 5-HT 2Aserotonin receptors selectively in primate brain". Neuropharmacology, Vol 37, 11471158.
60. Machado A. , Guilhardi P. ( 2000). "Shifts in the psychometric function and their implications for models of timing". J. Exp. Anal. Behav., Vol 74, 2554.
61. Martin J. R. , Ballard T. M. , Higgins G. A. ( 2002). "Influence of the 5-HT 2Creceptor antagonist, SB-242084, in tests of anxiety". Pharmacol. Biochem. Behav., Vol 71, 615625.
62. Martin J. R. , Bos M. , Jenck F. , Moreau J. , Mutel V. , Sleight A. J. , Wichmann J. , Andrews J. S. , Berendsen H. H. , Broekkamp C. L. , Ruigt G. S. , Kohler C. , Delft A. M. ( 1998). "5-HT 2Creceptor agonists: Pharmacological characteristics and therapeutic potential". J. Pharmacol. Exp. Ther., Vol 286, 913924.
63. Matell M. S. , Meck W. H. ( 1999). "Reinforcement-induced within-trial resetting of an internal clock". Behav. Proc., Vol 45, 157171.
64. Meck W. H. ( 1996). "Neuropharmacology of timing and time perception". Brain Res. Cogn. Brain Res., Vol 3, 227242.
65. Nelson D. L. , Lucaites V. L. , Wainscott D. B. , Glennon R. A. ( 1999). "Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT 2A, 5-HT 2Band 5-HT 2Creceptors". Naunyn Schmiedeberg’s Arch. Pharmacol., Vol 359, 16.
66. Olarte-Sánchez C. M. , Valencia-Torres L. , Cassaday H. J. , Bradshaw C. M. , Szabadi E. ( 2013). "Effects of SKF-83566 and haloperidol on performance on progressive ratio schedules maintained by sucrose and corn oil reinforcement: Quantitative analysis using a new model derived from the Mathematical Principles of Reinforcement (MPR)". Psychopharmacology, Vol 230, 617630.
67. Papakosta V.-M. , Kalogerakou S. , Kontis D. , Anyfandi E. , Theochari E. , Boulougouris V. , Papadopoulos S. , Panagis G. , Tsaltas E. ( 2013). "5-HT 2Creceptor involvement in the control of persistence in the reinforced spatial alternation animal model of obsessive–compulsive disorder". Behav. Brain Res., Vol 243, 176183.
68. Pehek E. A. , McFarlane H. G. , Maguschak K. , Price B. , Pluto C. P. ( 2001). "M100,907, a selective 5-HT(2A) antagonist, attenuates dopamine release in the rat medial prefrontal cortex". Brain Res., Vol 888, 5159.
69. Pehek E. A. , Nocjar C. , Roth B. L. , Byrd T. A. , Mabrouk O. S. ( 2006). "Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex". Neuropsychopharmacology, Vol 31, 265277.
70. Porter R. H. P. , Benwell K. R. , Lamb H. , Malcolm C. S. , Allen N. H. , Revell D. F. , Adams D. R. , Sheardown M. J. ( 1999). "Functional characterization of agonists at recombinant human 5-HT 2A, 5-HT 2Band 5-HT 2Creceptors in CHO-K1 cells". Br. J. Pharmacol., Vol 128, 1320.
71. Quarta D. , Naylor C. G. , Stolerman I. P. ( 2007). "The serotonin 2C receptor agonist Ro-60-0175 attenuates effects of nicotine in the five-choice serial reaction time task and in drug discrimination". Psychopharmacology, Vol 193, 391402.
72. Rényi L. , Larsson L. G. , Berg S. , Svensson B. E. , Thorell G. , Ross S. B. ( 1991). "Biochemical and behavioural effects of isamoltane, a beta-adrenoceptor antagonist with affinity for the 5-HT 1Breceptor of rat brain". Naunyn Schmiedeberg’s Arch. Pharmacol., Vol 343, 16.
73. Roberts D. C. S. , Loh E. A. , Baker G. B. , Vickers G. ( 1994). "Lesions of central serotonin systems affect responding on a progressive ratio schedule reinforced either by intravenous cocaine or by food". Pharmacol. Biochem. Behav., Vol 49, 177182.
74. Schepisi C. , De Carolis L. , Nencini P. ( 2013). "Effects of the 5HT 2Cantagonist SB242084 on the pramipexole-induced potentiation of water contrafreeloading, a putative animal model of compulsive behaviour". Psychopharmacology, Vol 227, 5566.
75. Shimazoe T. , Nakamura S. , Kobayashi K. , Watanabe S. , Miyasaka K. , Kono K. , Funakoshi A. ( 2004). "Role of 5-HT 1Breceptors in entrainment disorder of Otsika Long Evans Tokushima Fatty (OLETF) rats". Neuroscience, Vol 123, 201205.
76. Stubbs D. A. ( 1976). "Scaling of stimulus durations by pigeons". J. Exp. Anal. Behav., Vol 26, 1525.
77. Stubbs D. A. ( 1980). "Temporal discrimination and a free-operant psychophysical procedure". J. Exp. Anal. Behav., Vol 33, 167185.
78. Wogar M. A. , Bradshaw C. M. , Szabadi E. ( 1991). "Evidence for an involvement of 5-hydroxytryptaminergic neurones in the maintenance of operant behaviour by positive reinforcement". Psychopharmacology, Vol 105, 119124.
79. Zaniewska M. , McCreary A. C. , Przegalinski E. , Filip M. ( 2007). "Effects of the serotonin 5-HT 2Aand 5-HT 2Creceptor ligands on the discriminative stimulus effects of nicotine in rats". Eur. J. Pharmacol., Vol 571, 156165.

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