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Bernhard Sabel and ‘Residual Vision Activation Theory’: a History Spanning Three Decades

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This review has the purpose of retracing the work of Professor Bernard Sabel and his group over the last 2–3 decades, in order to understand how they achieved formulation of the ‘Residual Vision Activation Theory’. The methodology proposed is described, from the first studies in 1995 with High Resolution Perimetry requiring a six-months training period, to the new technologies, such as repetitive transorbital Alternating Current Stimulation, that require ten days of training. Vision restoration therapy has shown improvement in visual responses irrespective of age at the training, lesion aetiology and site of lesion. The hypothesis that visual training may induce network plasticity, improving neuronal networks in cortical and subcortical areas of both hemispheres, appears to be confirmed by recent studies including observation of the cerebral activity by fMRI and EEG. However, the results are quite variable and the mechanisms that influence cerebral activity are still unclear. The residual vision activation theory has been much criticized, both for its methodology and analysis of the results, but it gave a new impulse to the research in this area, stimulating more studies on induced cerebral plasticity.

Affiliations: 1: 1National Centre of Services and Research for Prevention of Blindness and Rehabilitation of Visually Impaired, Rome, Italy; 2: 2Pediatric Neurology Unit, Catholic University, Rome, Italy

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1. Alderman N. , Fry R. K. , Youngson H. A. ( 1995). "Improvement of self-monitoring skills, reduction of behavior disturbance and dysexecutive syndrome: comparison of response cost and a new program of self-monitoring training", Neuropsychol. Rehabil. Vol 5, 193221. http://dx.doi.org/10.1080/09602019508401467
2. Barbur J. L. , Watson J. D. , Frackowiak R. S. , Zeki S. ( 1993). "Conscious visual perception without V1", Brain Vol 116, 12931302. http://dx.doi.org/10.1093/brain/116.6.1293
3. Bien A. , Seidenbecher C. I. , Böckers T. M. , Sabel B. A. , Kreutz M. R. ( 1999). "Apoptotic versusnecrotic characteristics of retinal ganglion cell death after partial optic nerve injury", J. Neurotrauma Vol 16, 153163. http://dx.doi.org/10.1089/neu.1999.16.153
4. Bola M. , Gall C. , Sabel B. A. ( 2013a). "‘Sightblind’: perceptual deficits in the ‘intact’ visual field", Front. Neurol. Vol 4, 80. DOI: . http://dx.doi.org/10.3389/fneur.2013.00080
5. Bola M. , Gall C. , Sabel B. A. ( 2013b). "The second face of blindness: processing speed deficits in the intact visual field after pre- and post-chiasmatic lesions", PLoS ONE Vol 8, e63700. DOI: . http://dx.doi.org/10.1371/journal.pone.0063700
6. Brindley P. , Copeland M. , Demain C. , Martyn P. ( 1989). "A comparison of the speech of ten chronic Broca’s aphasics following intensive and non-intensive periods of therapy", Aphasiology Vol 3, 695707. http://dx.doi.org/10.1080/02687038908249037
7. Burke W. H. , Zencius A. H. , Wesolowski M. D. , Doubleday F. ( 1991). "Improving executive function disorders in brain-injured clients", Brain Inj. Vol 5, 241252. http://dx.doi.org/10.3109/02699059109008095
8. Cohen L. G. , Celnik P. , Pascual-Leone A. , Corwell B. , Falz L. , Dambrosia J. , Honda M. , Sadato N. , Gerloff C. , Catalá M. D. , Hallett M. ( 1997). "Functional relevance of cross-modal plasticity in blind humans", Nature Vol 11, 180183. http://dx.doi.org/10.1038/38278
9. Diller L. , Riley E. ( 1993). "The behavioral management of neglect", in: Unilateral Neglect: Clinical and Experimental Studies, Robertson I. H. , Marshall J. C. (Eds), pp.  293310. Lawrence Erlbaum Associates, Hillsdale, NJ, USA.
10. Fedorov A. , Jobke S. , Bersnev V. , Chibisova A. , Chibisova Y. , Gall C. , Sabel B. A. ( 2011). "Restoration of vision after optic nerve lesions with noninvasive transorbital alternating current stimulation: a clinical observational study", Brain Stimul. Vol 4, 189201. http://dx.doi.org/10.1016/j.brs.2011.07.007
11. Gall C. , Müller I. , Kaufmann C. , Sabel B. A. ( 2006). Effects of long-term use of Vision Restoration Therapy (VRT) and stability of visual field improvements >3 years, in: 67th AAPM&R Annual Assembly, Nov. 9–12, Honolulu, HI, USA.
12. Gall C. , Mueller I. , Gudlin J. , Lindig A. , Schlueter D. , Jobke S. , Franke G. H. , Sabel B. A. ( 2008a). "Vision- and health-related quality of life before and after vision restoration training in cerebrally damaged patients", Restor. Neurol. Neurosci. Vol 26, 341353.
13. Gall C. , Mueller I. , Kaufmann C. , Franke G. H. , Sabel B. A. ( 2008b). "Visual field defects after cerebral lesions from the patient’s perspective: health- and vision-related quality of life assesseb by SF-36 and NEI-VFQ", Nervenarzt Vol 79, 185194. http://dx.doi.org/10.1007/s00115-007-2342-9
14. Gall C. , Lucklum J. , Sabel B. A. , Franke G. H. ( 2009). "Vision- and health-related quality of life in patients with visual field loss after postchiasmatic lesions", Invest. Ophthalmol. Vis. Sci. Vol 50, 27652776. http://dx.doi.org/10.1167/iovs.08-2519
15. Gall C. , Franke G. H. , Sabel B. A. ( 2010). "Vision-related quality of life in first stroke patients with homonymous visual field defects", Health Qual. Life Outcomes Vol 8, 33. DOI: . http://dx.doi.org/10.1186/1477-7525-8-33
16. Gall C. , Sgorzaly S. , Schmidt S. , Brandt S. , Fedorov A. , Sabel B. A. ( 2011). "Noninvasive transorbital alternating current stimulation improves subjective visual functioning and vision-related quality of life in optic neuropathy", Brain Stimul. Vol 4, 175188. http://dx.doi.org/10.1016/j.brs.2011.07.003
17. Gall C. , Antal A. , Sabel B. A. ( 2013). "Non-invasive electrical brain stimulation induces vision restoration in patients with visual pathway damage", Graefes Arch. Clin. Exp. Ophthalmol. Vol 251, 10411043. http://dx.doi.org/10.1007/s00417-012-2084-7
18. Glisson C. C. , Galetta S. L. ( 2007). "Visual rehabilitation: now you see it; now you don’t", Neurology Vol 68, 18811882. http://dx.doi.org/10.1212/01.wnl.0000267412.54793.38
19. Gothe J. , Brandt S. A. , Irlbacher K. , Röricht S. , Sabel B. A. , Meyer B. U. ( 2002). "Changes in visual cortex excitability in blind subjects as demonstrated by transcranial magnetic stimulation", Brain Vol 125, 479490. http://dx.doi.org/10.1093/brain/awf045
20. Gudlin J. , Mueller I. , Thanos S. , Sabel B. A. ( 2008). "Computer based vision restoration therapy in glaucoma patients: a small open pilot study", Restor. Neurol. Neurosci. Vol 26, 403412.
21. Horton J. C. ( 2005a). "Disappointing results from Nova Vision’s restitution therapy", Br. J. Ophthalmol. Vol 89, 12. http://dx.doi.org/10.1136/bjo.2004.058214
22. Horton J. C. ( 2005b). "Vision restoration therapy: confounded by eye movements", Br. J. Ophthalmol. Vol 89, 792794. http://dx.doi.org/10.1136/bjo.2005.072967
23. Jobke S. , Kasten E. , Sabel B. A. ( 2009). "Vision restoration through extrastriate stimulation in patients with visual field defects: a double-blind and randomized experimental study", Neurorehabil. Neural Repair Vol 23, 246255. http://dx.doi.org/10.1177/1545968308324221
24. Kasten E. , Sabel B. A. ( 1995). "Visual field enlargement after computer training in brain-damaged patients with homonymous deficits: an open pilot trial", Restor. Neurol. Neurosci. Vol 8, 113127.
25. Kasten E. , Strasburger H. , Sabel B. A. ( 1997). "Programs for diagnosis and therapy of visual field deficits in vision rehabilitation", Spat. Vis. Vol 10, 499503. http://dx.doi.org/10.1163/156856897X00456
26. Kasten E. , Wuest S. , Sabel B. A. ( 1998a). "Residual vision in transition zones in patients with cerebral blindness", J. Clin. Exp. Neuropsychol. Vol 20, 581598. http://dx.doi.org/10.1076/jcen.20.5.581.1129
27. Kasten E. , Wüst S. , Behrens-Baumann W. , Sabel B. A. ( 1998b). "Computer-based training for the treatment of partial blindness", Nat. Med. Vol 4, 10831087. http://dx.doi.org/10.1038/2079
28. Kasten E. , Poggel D. A. , Sabel B. A. ( 2000). "Computer-based training of stimulus detection improves color and simple pattern recognition in the defective field of hemianopic subjects", J. Cogn. Neurosci. Vol 12, 10011012. http://dx.doi.org/10.1162/08989290051137530
29. Kasten E. , Müller-Oehring E. , Sabel B. A. ( 2001). "Stability of visual field enlargements following computer-based restitution training — results of a follow-up", J. Clin. Exp. Neuropsychol. Vol 23, 297305. http://dx.doi.org/10.1076/jcen.23.3.297.1180
30. Kasten E. , Bunzenthal U. , Sabel B. A. ( 2006). "Visual field recovery after vision restoration therapy (VRT) in independent of eye movements: an eye tracker study", Behav. Brain Res. Vol 175, 1826. http://dx.doi.org/10.1016/j.bbr.2006.07.024
31. Kerkhoff G. , Münßinger U. , Haaf E. , Eberle-Strauss G. , Stögerer E. ( 1992). "Rehabilitation of homonymous scotoma in patients with postgeniculate damage of the visual system: saccadic compensation training", Restor. Neurol. Neurosci. Vol 4, 245254.
32. Kerkhoff G. , Münßinger U. , Meier E. K. ( 1994). "Neurovisual rehabilitation in cerebral blindness", Arch. Neurol. Vol 51, 474481. http://dx.doi.org/10.1001/archneur.1994.00540170050016
33. Kreutz M. R. , Seidenbecher C. I. , Sabel B. A. ( 1999). "Molecular plasticity of retinal ganglion cells after partial optic nerve injury", Restor. Neurol. Neurosci. Vol 14, 127134.
34. Marshall R. S. , Ferrera J. J. , Barnes A. , Zhang X. , O’Brien K. A. , Chmayssani M. , Hirsch J. , Lazar R. M. ( 2008). "Brain activity associated with stimulation therapy of the visual borderzone in hemianopic stroke patients", Neurorehabil. Neural Repair Vol 22, 136144. http://dx.doi.org/10.1177/1545968307305522
35. McFadzean R. M. ( 2006). "NovaVision: vision restoration therapy", Curr. Opin. Ophthalmol. Vol 17, 498503. http://dx.doi.org/10.1097/ICU.0b013e3280108544
36. Meyer B. U. , Diehl R. , Steinmetz H. , Britton T. C. , Benecke R. ( 1991). "Magnetic stimuli applied over motor cortex and visual cortex: influence of coil position and field polarity on motor responses, phosphenes, and eye movements", Electroencephalogr. Clin. Neurophysiol. Suppl. Vol 43, 121134.
37. Mueller I. , Mast H. , Sabel B. A. ( 2007). "Recovery of visual field defects: a large clinical observational study using vision restoration therapy", Restor. Neurol. Neurosci. Vol 25, 563572.
38. Pambakian A. L. , Wooding D. S. , Patel N. , Morland A. B. , Kennard C. , Mannan S. K. ( 2000). "Scanning the visual world: a study of patients with homonymous hemianopia", J. Neurol. Neurosurg. Psychiatry Vol 69, 751759. http://dx.doi.org/10.1136/jnnp.69.6.751
39. Plant G. T. ( 2005). "A work out hemianopia", Br. J. Ophthalmol. Vol 89, 2. http://dx.doi.org/10.1136/bjo.2004.053173
40. Poggel D. A. , Mueller I. , Kasten E. , Sabel B. A. ( 2008). "Multifactorial predictors and outcome variables of vision restoration training in patients with post-geniculate visual field loss", Rest. Neurol. Neuruosci. Vol 26, 321339.
41. Pommerenke K. , Markowitsch H. J. ( 1989). "Rehabilitation training of homonymous visual field defects in patients with postgeniculate damage of the visual system", Restor. Neurol. Neurosci. Vol 1, 4763.
42. Pouget M. C. , Lévy-Bencheton D. , Prost M. , Tilikete C. , Husain M. , Jacquin-Courtois S. ( 2012). "Acquired visual field defects rehabilitation: critical review and perspectives", Ann. Phys. Rehabil. Med. Vol 55, 5374. http://dx.doi.org/10.1016/j.rehab.2011.05.006
43. Prilloff S. , Noblejas M. I. , Chedhomme V. , Sabel B. A. ( 2007). "Two faces of calcium activation after optic nerve trauma: live or death of retinal ganglion cells in vivodependes on calcium dynamics", Eur. J. Neurosci. Vol 25, 33393346. http://dx.doi.org/10.1111/j.1460-9568.2007.05550.x
44. Reinhard J. , Schreiber A. , Schiefer U. , Kasten E. , Sabel B. A. , Kenkel S. , Vonthein R. , Trauzettel-Klosinski S. ( 2005). "Does visual restitution training change absolute homonymous visual field defects? A fundus controlled study", Br. J. Ophthalmol. Vol 89, 3035. http://dx.doi.org/10.1136/bjo.2003.040543
45. Sabel B. A. ( 1997). "Unrecognized potential of surviving neurons: within-systems plasticity, recovery of function, and the hypothesis of minimal residual structure", Neuroscientist Vol 3, 366370. http://dx.doi.org/10.1177/107385849700300609
46. Sabel B. A. , Aschoff A. ( 1993). "Functional recovery and morphological changes after injury to the optic nerve", Neuropsychobiology Vol 28, 6265. http://dx.doi.org/10.1159/000119001
47. Sabel B. A. , Gudlin J. ( 2014). "Vision restoration training for glaucoma: a randomized clinical trial", JAMA Ophthalmol. Vol 132, 381389. http://dx.doi.org/10.1001/jamaophthalmol.2013.7963
48. Sabel B. A. , Kasten E. , Kreutz M. R. ( 1997). "Recovery of vision after partial visual system injury as a model of postlesion neuroplasticity", Adv. Neurol. Vol 73, 251276.
49. Sabel B. A. , Henrich-Noack P. , Fedorov A. , Gall C. ( 2011a). "Vision restoration after brain and retina damage: the ‘residual vision activation theory’", Prog. Brain Res. Vol 192, 199262.
50. Sabel B. A. , Fedorov A. B. , Naue N. , Borrmann A. , Herrmann C. , Gall C. ( 2011b). "Non-invasive alternating current stimulation improves vision in optic neuropathy", Restor. Neurol. Neurosci. Vol 29, 493505.
51. Sabel B. A. , Kruse R. , Guenther T. ( 2013). "Local topographic influences on vision restoration hot spots after brain damage", Restor. Neurol. Neurosci. Vol 31, 87803.
52. Schoenfeld M. A. , Heinze H. J. , Woldorff M. G. ( 2002a). "Unmasking motion-processing activity in human brain area V5/MT+ mediated by pathways that bypass primary visual cortex", NeuroImage Vol 17, 769779. http://dx.doi.org/10.1006/nimg.2002.1204
53. Schoenfeld M. A. , Noesselt T. , Poggel D. , Tempelmann C. , Hopf J.-M. , Woldorff M. G. , Heinze H.-J. , Hillyard S. A. ( 2002b). "Analysis of pathways mediating preserved vision after striate cortex lesions", Ann. Neurol. Vol 52, 814824. http://dx.doi.org/10.1002/ana.10394
54. Schwartz M. S. ( 1995). "Adults with traumatic brain injury: three case studies of cognitive rehabilitation in home setting", Am. J. Occup. Ther. Vol 49, 655667. http://dx.doi.org/10.5014/ajot.49.7.655
55. Zeki S. , Ffytche D. H. ( 1998). "The Riddoch syndrome: insights into the neurobiology of conscious vision", Brain Vol 121, 2545. http://dx.doi.org/10.1093/brain/121.1.25
56. Zihl J. ( 1980). Untersuchung von Sehfunktionen bei Patientenmiteiner Schädigung der zentralenvisuellen Systems unter besonderer Berücksichtigung der Restitution dieser Funktionen, Habilitationsschrift, München, Germany.
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2015-04-30
2018-11-21

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