Cookies Policy

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

Evaluating the anti-diabetic effects of Sarcopoterium spinosum extracts in vitro

No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.

Brill’s MyBook program is exclusively available on BrillOnline Books and Journals. Students and scholars affiliated with an institution that has purchased a Brill E-Book on the BrillOnline platform automatically have access to the MyBook option for the title(s) acquired by the Library. Brill MyBook is a print-on-demand paperback copy which is sold at a favorably uniform low price.

Access this article

+ Tax (if applicable)
Add to Favorites
You must be logged in to use this functionality

image of Israel Journal of Plant Sciences

Natural medicine has traditionally used medicinal plants to treat diabetes. However, the efficacy of most of these folk medicine plants has rarely been tested and validated using scientific methods. Sarcopoterium spinosum, an abundant plant in Israel, was suggested to have a beneficial effect on diabetes symptoms. In this study we determined the antidiabetic effect of an S. spinosum extract in vitro.Results: Treatment of L6 myotubes with an S. spinosum extract induced GSK3β phosphorylation, suggesting that the extract increases glycogen synthesis. In pancreatic β-cells, the S. spinosum extract increased basal insulin secretion, but reduced glucose/forskolin-induced insulin secretion. The extract also inhibited isoproterenol-induced lipolysis in 3T3-L1 adipocytes, as determined by measuring the free fatty acids in the supernatant.Conclusion: The study shows that S. spinosum extract affects insulin secretion in pancreatic β-cells, and has insulin-like effects on metabolic pathways in classic insulin-responsive tissues. In vivo studies in diabetic animals will be performed in order to validate the in vitro study.

Affiliations: 1: Department of Molecular Biology ; 2: Department of Nutrition, Ariel University Center of Samaria ; 3: Samaria and Jordan Rift R&D Center


Full text loading...


Data & Media loading...

1. Ahren, B. 2005. Type 2 diabetes, insulin secretion and betacell mass. Curr. Mol. Med. 5(3): 275-286.
2. Ali-Shtayeh, M. S., Yaniv, Z., Mahajna, J. 2000. Ethnobotanical survey in the Palestinian area: a classification of the healing potential of medicinal plants. J. Ethnopharmacol. 73(1-2): 221-232.
3. Bouche, C., Serdy, S., Kahn, C. R., Goldfine, A. B. 2004. The cellular fate of glucose and its relevance in type 2 diabetes. Endocr. Rev. 25(5): 807-830.
4. Chakraborty, C. 2006. Biochemical and molecular basis of insulin resistance. Curr. Protein Pept. Sci. 7(2): 113-121.
5. Chang, L., Chiang, S. H., Saltiel, A. R. 2004. Insulin signaling and the regulation of glucose transport. Mol. Med. 10(7-12): 65-71.
6. Chaturvedi, N. 2007 The burden of diabetes and its complications: trends and implications for intervention. Diabetes Res. Clin. Pract. 76 1 S3-12.
7. Chen, D., Wang, M. W. 2005. Development and application of rodent models for type 2 diabetes. Diabetes Obes. Metab. 7(4): 307-317.
8. Cicero, A. F., Derosa, G., Gaddi, A. 2004. What do herbalists suggest to diabetic patients in order to improve glycemic control? Evaluation of scientific evidence and potential risks. Acta Diabetol. 41(3): 91-98.
9. Cnop, M., Welsh, N., Jonas, J. C., Jorns, A., Lenzen, S., Eizirik, D. L. 2005. Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes 54 Suppl 2 S97-107.
10. Dafni, A., Yaniv, Z., Palevitch, D. 1984. Ethnobotanical survey of medicinal-plants in Northern Israel. J. Ethnopharmacol. 10(3): 295-310.
11. Devendra, D., Liu, E., Eisenbarth, G. S. 2004. Type 1 diabetes: recent developments. Br. Med. J. 328(7442): 750-754.
12. Frame, S., Zheleva, D. 2006. Targeting glycogen synthase kinase-3 in insulin signalling. Expert Opin. Ther. Targets 10(3): 429-444.
13. Frost, S. C., Lane, M. D. 1985. Evidence for the involvement of vicinal sulfhydryl groups in insulin-activated hexose transport by 3T3-L1 adipocytes. J. Biol. Chem. 260(5): 2646-2652.
14. Giorgino, F., Laviola, L., Leonardini, A. 2005. Pathophysiology of type 2 diabetes: rationale for different oral antidiabetic treatment strategies. Diabetes Res. Clin. Pract. 68 Suppl1 S22-S29.
15. Hamdan, I. I., Afifi, F. U. 2004. Studies on the in vitro and in vivo hypoglycemic activities of some medicinal plants used in treatment of diabetes in Jordanian traditional medicine. J. Ethnopharmacol. 93(1): 117-121.
16. Henriksen, E. J., Dokken, B. B. 2006. Role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes. Curr. Drug Targets 7(11): 1435-1441.
17. Ivorra, M. D., Paya, M., Villar, A. 1989. A review of natural products and plants as potential antidiabetic drugs. J. Ethnopharmacol. 27(3): 243-275.
18. Kanter, Y., Teicher, D., Wiener, F., Lesman, T., Mandelbaum, A. 1983. The response to oral glucose among diabetic and normal rats primed with Poterium spinosum extracts. Is. J. Med. Sci. 19: 304-308.
19. Kraemer, F. B., Shen, W. J. 2002. Hormone-sensitive lipase: control of intracellular tri-(di-)acylglycerol and cholesteryl ester hydrolysis. J. Lipid Res. 43(10): 1585-1594.
20. Kralisch, S., Klein, J., Lossner, U., Bluher, M., Paschke, R., Stumvoll, M., Fasshauer, M. 2005. Isoproterenol, TNFalpha, and insulin downregulate adipose triglyceride lipase in 3T3-L1 adipocytes. Mol. Cell Endocrinol. 240(1-2), 43-49.
21. Kulkarni, R. N., Wang, Z. L., Wang, R. M., Hurley, J. D., Smith, D. M., Ghatei, M. A., Withers, D. J., Gardiner, J. V., Bailey, C. J., Bloom, S. R. 1997. Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. J. Clin. Invest. 100(11): 2729-2736.
22. Large, V., Peroni, O., Letexier, D., Ray, H., Beylot, M. 2004. Metabolism of lipids in human white adipocyte. Diabetes Metab. 30(4): 294-309.
23. Lev-Yadun, S. 1997. Flora and climate in southern Samaria: past and present. In: Finkelstain, I., Llederman, Z., eds. Highlands of many cultures. The Institute of Archeology, Tel AViv University, Tel Aviv, pp. 85-102.
24. Long, Y. C., Zierath, J. R. 2006. AMP-activated protein kinase signaling in metabolic regulation. J. Clin. Invest. 116(7), 1776-1783.
25. Perevolotsky, A., Pollak, G. 2000. Ecology: theory and the Israeli experience. Carta, Jerusalem, Israel, pp. 474-473 (in Hebrew).
26. Rees, D. A., Alcolado, J. C. 2005. Animal models of diabetes mellitus. Diabetes Med. 22(4): 359-370.
27. Saad, B., Azaizeh, H., Said, O. 2005. Tradition and perspectives of Arab herbal medicine. eCAM 2(4): 475-479.
28. Shani, J., Joseph, B., Sulman, F. G. 1970. Fluctuations in the hypoglycaemic effect of Poterium spinosum L. (Rosaceae). Arch. Int. Pharmacodyn. Ther. 185(2): 344-349.
29. Smyth, S., Heron, A. 2006. Diabetes and obesity: the twin epidemics. Nat. Med. 12(1): 75-80.
30. Yaniv, Z., Dafni, A., Friedman, J., Palevitch, D. 1987. Plants used for the treatment of diabetes in Israel. J. Ethnopharmacol. 19(2): 145-151.
31. Yildiz, B. O., Haznedaroglu, I. C. 2006. Rethinking leptin and insulin action: therapeutic opportunities for diabetes. Int. J. Biochem. Cell Biol. 38(5-6): 820-830.
32. Yin, W., Mu, J., Birnbaum, M. J. 2003. Role of AMP-activated protein kinase in cyclic AMP-dependent lipolysis in 3T3-L1 adipocytes. J. Biol. Chem. 278(44): 43074-43080.
33. Zhao, Y. F., Feng, D. D., Chen, C. 2006. Contribution of adipocyte-derived factors to beta-cell dysfunction in diabetes. Int. J. Biochem. Cell Biol. 38(5-6): 804-819.
34. Zohary, M., Feinbrun-Dothan, N. 1966. Flora Palaestina, part 4. Israel Academy of Science and Humanitites, Jerusalem, 136 pp.

Article metrics loading...



Can't access your account?
  • Tools

  • Add to Favorites
  • Printable version
  • Email this page
  • Subscribe to ToC alert
  • Get permissions
  • Recommend to your library

    You must fill out fields marked with: *

    Librarian details
    Your details
    Why are you recommending this title?
    Select reason:
    Israel Journal of Plant Sciences — Recommend this title to your library
  • Export citations
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation