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Lipid lowering effect of hot water extract of Trichosanthes cucumerina Linn. and antihyperglycemic activity of its fractions on streptozotocin-induced diabetic rats

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Trichosanthes cucumerina Linn (Family: Cucurbitaceae) is a climber grown in Asian countries including Sri Lanka, India, the Malay Penisula, and The Philippines. It is known as dummella in Sinhalese, wild snake gourd in English, kattuppeyppudal in Tamil, and janglichichonda in Hindi. A previous study has shown that hot water extract (HWE) of T. cucumerina can exert significant antihyperglycemic activity in rats. The present study was carried out to investigate the effects of the HWE of T. cucumerina aerial parts on lipid profile of streptozotocin (STZ)-induced Type 1 and Type 2 diabetic rats. In addition, an attempt has been made to identify the active antidiabetic fraction/s of T. cucumerina HWE using streptozotocin (STZ)-induced Type 1 diabetic rats. There was a significant (p ≤ 0.05) decrease in total cholesterol, low density lipoprotein, and triglycerides levels, and a significant (p ≤ 0.05) increase in high density lipoprotein level in the HWE-treated Type 1 and Type 2 diabetic rats compared to their respective controls. In addition, maximum antidiabetic effect was observed in the AQF (aqueous fraction) of the HWE. This study reveals the hypolipidemic and antihyperglycemic effects of T. cucumerina aerial parts.

Affiliations: 1: Industrial Technology Institute, Bauddhaloka Mawatha ; 2: Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo ; 3: Industrial Technology Institute


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